*Indicates changes from 2015
#Indicates driver to miss start of 2016 season
^Indicates driver will not make every start in car (Michael Waltrip will drive the No. 83 in the Daytona 500, Matt DiBenedetto will drive a third entry for BK Racing.)
2016 NASCAR Sprint Cup Series drivers
| Car Number | Driver | Crew Chief | Manufacturer | Team |
|---|---|---|---|---|
| 1 | Jamie McMurray | Matt McCall | Chevrolet | Chip Ganassi Racing with Felix Sabates |
| 2 | Brad Keselowski | Paul Wolfe | Ford | Team Penske |
| 3 | Austin Dillon | Slugger Labbe | Chevrolet | Richard Childress Racing |
| 4 | Kevin Harvick | Rodney Childers | Chevrolet | Stewart-Haas Racing |
| 5 | Kasey Kahne | Keith Rodden | Chevrolet | Hendrick Motorsports |
| 6 | Trevor Bayne | Matt Puccia* | Ford | Roush Fenway Racing |
| 7 | Regan Smith* | Tommy Baldwin Jr.* | Chevrolet | Tommy Baldwin Racing |
| 10 | Danica Patrick | Billy Scott* | Chevrolet | Stewart-Haas Racing |
| 11 | Denny Hamlin | Mike Wheeler* | Toyota | Joe Gibbs Racing |
| 13 | Casey Mears | Bootie Barker | Chevrolet | Germain Racing |
| 14 | Tony Stewart# | Mike Bugarewicz* | Chevrolet | Stewart-Haas Racing |
| 15 | Clint Bowyer | Steve Addington | Chevrolet* | HScott Motorsports* |
| 16 | Greg Biffle | Brian Pattie* | Ford | Roush Fenway Racing |
| 17 | Ricky Stenhouse Jr. | Nick Sandler | Ford | Roush Fenway Racing |
| 18 | Kyle Busch | Adam Stevens | Toyota | Joe Gibbs Racing |
| 19 | Carl Edwards | Dave Rogers* | Toyota | Joe Gibbs Racing |
| 20 | Matt Kenseth | Jason Ratcliff | Toyota | Joe Gibbs Racing |
| 21 | Ryan Blaney | Jeremy Bullins | Ford | Wood Brothers Racing |
| 22 | Joey Logano | Todd Gordon | Ford | Team Penske |
| 23 | David Ragan* | Patrick Donahue* | Toyota | BK Racing |
| 24 | Chase Elliott* | Alan Gustafson | Chevrolet | Hendrick Motorsports |
| 27 | Paul Menard | Justin Alexander | Chevrolet | Richard Childress Racing |
| 31 | Ryan Newman | Luke Lambert | Chevrolet | Richard Childress Racing |
| 32 | Jeffrey Earnhardt*/Bobby Labonte | Wally Rogers* | Ford | Go FAS Racing |
| 34 | Chris Buescher* | Bob Osborne* | Ford | Front Row Motorsports |
| 38 | Landon Cassill* | Donnie Wingo | Ford | Front Row Motorsports |
| 41 | Kurt Busch | Tony Gibson | Chevrolet | Stewart-Haas Racing |
| 42 | Kyle Larson | Chad Johnston* | Chevrolet | Chip Ganassi Racing with Felix Sabates |
| 43 | Aric Almirola | Trent Owens | Ford | Richard Petty Motorsports |
| 44* | Brian Scott* | Chris Heroy* | Ford* | Richard Petty Motorsports* |
| 46 | Michael Annett | Jay Guy | Chevrolet | HScott Motorsports |
| 47 | AJ Allmendinger | Randall Burnett* | Chevrolet | JTG Daugherty |
| 48 | Jimmie Johnson | Chad Knaus | Chevrolet | Hendrick Motorsports |
| 78 | Martin Truex Jr. | Cole Pearn | Toyota* | Furniture Row Racing |
| 83 | Matt DiBenedetto^ | Gene Nead | Toyota | BK Racing |
| 88 | Dale Earnhardt Jr. | Greg Ives | Chevrolet | Hendrick Motorsports |
| 95 | Michael McDowell/Ty Dillon* | Dave Winston* | Chevrolet* | Circle Sport — Leavine Family Racing* |
| 98 | Cole Whitt* | Mark Hillman* | TBA | Premium Motorsports |