| No. | Driver | Sponsor | Make | Organization |
| 00 | Landon Cassill | William Hill Sports Book | Chevrolet | StarCom Racing |
| 1 | Kurt Busch | GearWrench | Chevrolet | Chip Ganassi Racing |
| 2 | Brad Keselowski | AutoTrader | Ford | Team Penske |
| 3 | Austin Dillon | Bass Pro Shops / Tracker Off-Road | Chevrolet | Richard Childress Racing |
| 4 | Kevin Harvick | Mobil 1 | Ford | Stewart-Haas Racing |
| 6 | Ryan Newman | Oscar Mayer Bacon | Ford | Roush Fenway Racing |
| 8 | Daniel Hemric | Cessna | Chevrolet | Richard Childress Racing |
| 9 | Chase Elliott | NAPA Filters | Chevrolet | Hendrick Motorsports |
| 10 | Aric Almirola | Smithfield | Ford | Stewart-Haas Racing |
| 11 | Denny Hamlin | FedEx Ground | Toyota | Joe Gibbs Racing |
| 12 | Ryan Blaney | PPG | Ford | Team Penske |
| 13 | Ty Dillon | GEICO | Chevrolet | Germain Racing |
| 14 | Clint Bowyer | TOCO Warranty | Ford | Stewart-Haas Racing |
| 15 | Ross Chastain | TBA | Chevrolet | Premium Motorsports |
| 17 | Ricky Stenhouse Jr. | SUNNYD | Ford | Roush Fenway Racing |
| 18 | Kyle Busch | M&M's Hazelnut | Toyota | Joe Gibbs Racing |
| 19 | Martin Truex Jr. | Bass Pro Shops | Toyota | Joe Gibbs Racing |
| 20 | Erik Jones | Craftsman Gas Monkey | Toyota | Joe Gibbs Racing |
| 21 | Paul Menard | Menards / Monster | Ford | Wood Brothers Racing |
| 22 | Joey Logano | Pennzoil | Ford | Team Penske |
| 24 | William Byron | Liberty University | Chevrolet | Hendrick Motorsports |
| 27 | Joe Nemechek | TBD | Chevrolet | Premium Motorsports |
| 32 | Corey LaJoie | Schluter Systems | Ford | Go Fas Racing |
| 34 | Michael McDowell | Love's Travel Stops | Ford | Front Row Motorsports |
| 36 | Matt Tifft | Surface / Maui Jim | Ford | Front Row Motorsports |
| 37 | Chris Buescher | Natural Light Seltzer | Chevrolet | JTG Daugherty Racing |
| 38 | David Ragan | Select Blinds | Ford | Front Row Motorsports |
| 41 | Daniel Suarez | Haas Automation | Ford | Stewart-Haas Racing |
| 42 | Kyle Larson | Clover | Chevrolet | Chip Ganassi Racing |
| 43 | Bubba Wallace | Victory Junction | Chevrolet | Richard Petty Motorsports |
| 47 | Ryan Preece | Kroger | Chevrolet | JTG Daugherty Racing |
| 48 | Jimmie Johnson | Ally | Chevrolet | Hendrick Motorsports |
| 51 | BJ McLeod | Jacob Companies | Chevrolet | Petty Ware Racing |
| 52 | Garrett Smithley | Honest Abe Roofing | Chevrolet | Rick Ware Racing |
| 53 | JJ Yeley | AQRE.app | Chevrolet | Rick Ware Racing |
| 66 | Joey Gase | Nevada Donor Network | Toyota | MBM Motorsports |
| 77 | Reed Sorenson | TBA | Chevrolet | Spire Motorsports |
| 88 | Alex Bowman | Nationwide | Chevrolet | Hendrick Motorsports |
| 95 | Matt DiBenedetto | Barstool Sports | Toyota | Leavine Family Racing |
Las Vegas Motor Speedway: South Point 400 Entry List
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